What Is Phosphagen? Role of Phosphagen in Organisms

Phosphagens were discovered by Philip Eggleton and his wife Grace Eggleton. Phosphagens are high-energy storage organic compounds. It is also known as macroergic compounds.

It contains phosphorous and nitrogen-based compounds so also called phosphorylated guanidino compounds that are found in the muscles, which supply energy on hydrolysis of phosphate.

These compounds allow a high-energy phosphate pool to be maintained in a proper concentration range, in which if all were ATP (adenosine triphosphate), that will cause problems due to the ATP-consuming reactions in these tissues.

As muscle tissues can have sudden demands of high energy, to fulfill the demands, phosphagen compounds can maintain the reserve of high-energy phosphates that can be utilized when needed.

To provide the immediate energy which could not be immediately supplied by glycolysis or oxidative phosphorylation this system is needed.

Phosphagens are found differently in invertebrates and vertebrates which means the actual biomolecule used as a phosphagen compound is dependent on the organism.

In the majority of organisms such as invertebrates arginine phosphate is present, and in chordates (i.e., animals with spinal cords) or vertebrates creatine phosphate acts as phosphagens.

Creatine phosphate is the most common phosphagen found in the muscles and nerves of vertebrates or chordates.

The enzyme creatine kinase forms the compound creatine phosphate or phosphocreatine in a reversible reaction.

These compounds provide immediate but limited energy during muscle contraction.

Phosphagen cycle

Recommended: Muscle related diseases

Leave a Comment